09 Jun 2026

Clinical Study Shows NeuroCuple® Reduced Pain and Opioid Use After Knee Replacement Surgery

Journal of Arthroplasty, Published Peer-Reviewed Research
New Evidence for Drug-Free Pain Relief Following Total Knee Replacement A newly published clinical study in The Journal of Arthroplasty has found that NeuroCuple® technology significantly reduced pain and opioid use following total knee replacement surgery. Total knee replacement is one of the most common orthopedic procedures performed worldwide. While the surgery can restore mobility and improve quality of life, many patients experience substantial postoperative pain that often requires opioid medications for relief. Researchers conducted a randomized, placebo-controlled clinical study to evaluate whether NeuroCuple® technology could help reduce pain and decrease reliance on opioid medications during the critical early recovery…
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10 Aug 2025

NCAP Medical Presents Preliminary NIH-Funded TKA Study Results at MHSRS 2025

Public Events, Published Peer-Reviewed Research
NCAP Medical, Inc. is pleased to announce that our Chief Medical Officer, Senthil Sadhasivam, MD, MBA, MPH, presented a scientific poster containing preliminary results from our ongoing NIH-funded total knee arthroplasty (TKA) outcome study, currently being conducted at the University of Pittsburgh Medical Center (UPMC). The work was featured at the Military Health System Research Symposium (MHSRS) — the Department of Defense’s premier multidisciplinary research meeting dedicated to optimizing the health and performance of U.S. service members. The event details can be found at the official MHSRS site:https://mhsrs.health.mil/ Background and Study Rationale Total knee arthroplasty remains one of the most…
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23 Oct 2024

A Major Clinical Step Forward: Evaluating the NeuroCuple® Device in Knee Replacement Surgery

ClinicalTrials.gov, Published Peer-Reviewed Research, , ,
When patients undergo a major procedure like total knee arthroplasty (TKA), managing pain safely is critical. Effective pain relief enables mobilization, shorter hospital stays, fewer complications—and, critically today, less reliance on opioid medications. That’s why the ongoing randomized controlled trial NCT06460350 is so important for the device manufacturer, clinicians, and patients alike. What is the Trial? Name: “NEUROCUPLE™ in TKA Patients to Enhance Pain Management” (ClinicalTrials.gov Identifier: NCT06460350) found here --> ClinicalTrials.gov Design: Randomized (1:1), placebo-controlled trial comparing the NeuroCuple® patch versus a look-alike placebo patch (without the active nano-capacitor array) in patients undergoing primary unilateral TKA. Scope: The device…
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28 Nov 2023

Clinical Evidence Update: NeuroCuple® Device Shows Significant Benefits in Postoperative Pain Management

Journal of Clinical Medicine, Published Peer-Reviewed Research, , , ,
  As postoperative pain management continues to evolve toward safer and more multimodal strategies, clinicians are seeking non-pharmacologic modalities capable of reducing opioid exposure without compromising analgesia or recovery outcomes. A recent peer-reviewed study published in the Journal of Clinical Medicine provides encouraging evidence that the NeuroCuple® device—a passive, battery-free nano-capacitive patch—may serve as a meaningful adjunct in early postoperative care. 🔗 Study link: https://www.mdpi.com/2077-0383/12/23/7394 Study Design Summary Conducted at UPMC Shadyside, this prospective, randomized, open-label pilot trial evaluated the NeuroCuple® device in opioid-naïve adults undergoing unilateral primary TKA or THA. Key elements: Participants randomized postoperatively to: Standard multimodal analgesia…
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13 Sep 2023

A New Approach to Post-Surgical Pain: How a Nano-Tech Device Helped a Knee Replacement Patient Avoid Opioids

Published Peer-Reviewed Research, PubMed,
Recovering from a total knee replacement is not easy. Pain levels are often intense, mobility is limited, and most patients are sent home with a prescription for opioid medications immediately after surgery. While these medications can help, they also bring risks—side effects, such as nausea, vomiting, drowsiness, constipation besides risk for dependence, and sometimes prolonged use long after recovery. Now imagine this:A patient undergoes knee replacement surgery, goes home, uses a simple drug-free patch, and never needs opioids at all. That is exactly what happened in a newly published peer-reviewed case report, where the NeuroCuple® device was used as part…
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